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Medical hair restoration in the literal sense includes the hair loss treatment which depends upon the use of medicines. Unusual hair loss both in men and women is caused by the alterations in the androgen metabolism. Androgen is a male hormone which has a major role to play in regulation of hair growth or hair loss. The dermal papilla is the most important structure in a hair follicle which is responsible for hair-growth. It is the dermal papilla, the cell of which divides and differentiates to give rise to a new hair follicle. The dermal papilla is in direct contact with blood capillaries in the skin to derive the nutrients for the growing hair follicle. Research has shown that dermal papilla got many receptors for androgens and there are studies which have confirmed that males have more androgenic receptors in dermal papilla of their follicles as compared to females. The metabolism of androgen involves an enzyme called 5 alpha reductase which combines with the hormone androgen(testosterone) to form the DHT (Dihydro-testosterone). DHT is a natural metabolite of our body which is the root cause of hair loss. Proper nutrition is critical for the maintenance of the hair. When DHT gets into the hair follicles and roots (dermal papilla), it prevents necessary proteins, vitamins and minerals from providing nourishment needed to sustain life in the hairs of those follicles. Consequently, hair follicles are reproduced at a much slower rate. This shortens their growing stage (anagen phase) and or lengthens their resting stage (telogen phase) of the follicle. DHT also causes hair follicle to shrink and get progressively smaller and finer. This process is known as miniaturization and causes the hair to ultimately fall. DHT is responsible for 95% of hair loss. Some individuals both men and women are genetically pre-disposed to produce more DHT than the normal individuals. DHT also creates a wax-like substance around the hair roots. It is this accumulation of DHT inside the hair follicles and roots which is one of the primary causes of male and female pattern hair loss. Blocking the synthesis of DHT at molecular level forms the basis for the treatment of MPHL ( male pattern hair loss) and FPHL female pattern hair loss). There are many natural DHT blockers and a number of drugs which are used for medical hair restoration. Let us see the main drugs which are available for medical hair restoration in men and women. Minoxidil Minoxidil has the distinction of the first drug being used for promoting the hair restoration. This medical hair restoration treatment drug was used earlier as an oral antihypertensive drug, but after its hypertrichosis (excessive body hair) effects were noticed, a topical solution of the drug was tested for its hair growing potential. Minoxidil was then approved as medical hair restoration treatment drug for men by the US Food and Drug Administration (FDA) in 1988 as a 2% solution, followed by 5% solution in 1997. For women, the 2% solution was approved in 1991. Though 5% solution is not approved for women, it is used as a medical hair restoration treatment by many dermatologists worldwide. Both solutions are available without a prescription in the US. Mechanism of action Minoxidil is thought to have a direct mitogenic effect on epidermal cells, as has been observed both in vitro in vivo. Though the mechanism of its action for causing cell proliferation is not very clear, minoxidil is thought to prevent intracellular calcium entry. Calcium normally enhances epidermal growth factors to inhibit hair growth, and Minoxidil by getting converted to minoxidil sulfate acts as a potassium channel agonist and enhances potassium ion permeability to prevent calcium ions from entering into cells. Thought the exact action of minoxidil preventing the formation of DHT has not been shown but the drug has been shown to have a stabilizing effect on the hair loss. The result of the drug takes about few months time to be evident since it is the time which is necessary for restoring the normal growth cycle of hair fibers. Use of Minoxidil has approved by FDA for men (Norwood II-V) and women (Ludwig I-II ) older than 18 years. It is used as a medical hair restoration treatment either for frontal or vertex scalp thinning. It brings about an increase in density which is mostly caused by conversion of miniaturized hairs into terminal hairs rather than a stimulated de novo re-growth. The hair loss becomes stabilized after continued use of drug, which takes about a year’s time for the medical hair restoration treatment to show its complete results. Hair loss restoration treatment with 0.05% betamethasone dipropionate and 5% topical minoxidil are found to be superior to minoxidil alone. Topical minoxidil is very well tolerated and adverse effects are mainly dermatologic. The most frequent adverse effect is an irritant contact dermatitis. Though minnoxidil does not have any effect on blood pressure, it should be used with caution in patient with cardiovascular diseases. It is also contraindicated in pregnant and nursing mothers. Finasteride The drug finasteride was earlier used as treatment for prostate enlargement, under the medical name Proscar. But in 1998, it was approved by FDA for the Medical hair loss restoration in MPHL. Mechanism of Action Medical hair restoration treatments with Finasteride depends upon its specific action as an inhibitor of type II 5α-reductase, the intracellular enzyme that converts male hormone androgen into DHT (Dihydro Testosterone). Its action results in significant decrease in serum and tissue DHT levels in even in concentration as low as 0.2mg. Finnasteride is able to stabilize hair loss in 80% of patient with Vertex hair loss and in 70% of patients with frontal hair loss. Most of these patients are able to grow more hair or retain the ones they have. The peculiar thing about Propecia is that its effect is more pronounced in crown area than in the front. The hair that grow after the medical hair restoration treatments are better in texture and are thicker, more like the terminal hair. The best thing about medical hair restoration treatment with the finnasteride is that it is well tolerated and has minimal side effects. Sexual dysfunction (decreased sex drive, erectile dysfunction, and decreased semen volume) are observed in about 3.8% of cases. But these side-effects subside within few months of Medical hair restoration treatments or disappear within a week’s time as soon as the treatment is stopped. It generally requires about 6 to 12 months for the m edical hair restoration treatment to be apparent but the side effects appear earlier. So even after the medicine is stopped, there is no possibility of loosing the hair that has been gained, but the side effects are sure to disappear. Many hair restoration surgeons find Propecia (finasteride) to act as an excellent adjunct to the surgical hair restoration. There are several benefits of this kind of combination therapy. As the Medical hair restoration with Propecia brings about a hair re-growth in the crown area, it has a complementary action; it allows the surgeon to have more donor hair to be available for frontal hair transplant and design the hairline at his own will. Since finasteride has no effect in the frontal area of the scalp, it does not have any interference with the surgical hair restoration. Combination Therapy There are reports which say that use of finasteride and topical minoxidil combination therapy as a Medical hair restoration treatment is of more advantage in cases of mild to moderate MPHL. Further studies are in progress. Many hair restoration doctors have already started the use of combination therapy in order to obtain better hair growth. Anti Androgen Therapy For women with hyperandrogonism( with increased levels of androgen) who do not respond well to minoxidil, antiandrogen therapy is another option of Medical hair restoration. In UK the most commonly used anti-androgen for women is CPA (cyproterone acetate), which is used in combination with ethinyl-estradiol. However, in United States, where CPA is not available, the aldosterone antagonist spironolactone is the alternative choice of hair restoration doctors. Flutamide Medical hair restoration with flutamide has shown improvement as hair loss restoration treatment in women with hirsutism. For hyperandrogenic premenopausal women, flutamide is a better medical hair restoration agent than both the CPA or finestride. Hair loss restoration management is a structured process which depends upon many factors along with the medical hair restoration. For more details on the topic you can refer to section medical hair restoration or article on male pattern hair loss or female pattern hair loss at our site hairtransplantadvice.com. penis enlargement supplement manual penis enlargement vimax penis enlargement without pills pennis enlargement surgery photo penis enlargement pills review penile enlargment excercises penis elargement pills product penis enlagement pump

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V for Victory, V for Viagra. Imagine how many marriages and relationships were saved due to Viagra and how many men have recuperated confidence on their manhood. Thanks to Viagra! This is a victory over human hopelessness. This has brought a new dimension and charm to distressed love life due to erectile dysfunction and premature ejaculation. And at the same time Viagra is rebel against the ageing factor. You are never too old to satisfy your partner and enjoy your love life to the fullest. But shall we take this as only one of the milestones, to its never-ending journey towards victory? Viagra is moving upwards to heal our hearts now. Greek researcher Michael Doumas MD, from the fourth department of internal medicine at the University of Athens in Greece says in American Society of Hypertension's 20th Annual Scientific Meeting and Exposition that research determined that men with high blood pressure are at the risk of erectile dysfunction, which is more than twice as high as men with normal blood pressure. Blood vessel wall dysfunction is a common defect with Men with ED and those suffering from atherosclerosis. The cells that cover the inner lining of blood vessels secrete important substances, such as nitric oxide, that help control vascular tone and the ability of the vessels to dilate. Charalambos Vlachopoulos, MD, of the first department of cardiology at Athens Medical School in Greece, examined the long-term effects of Viagra on blood vessel stiffness of the body's main artery. The use of Viagra for the treatment of hypertensive men with erectile dysfunction may change the vessel wall, increasing its elasticity. Blood flow in a vessel of the neck was measured in the beginning of the study and then again two weeks later. A measurement of blood flow that is called Pulse-wave velocity in medical language was taken 24 hours after the dose of Viagra. The researchers found that arterial stiffness decreased for men taking Viagra. Amazing is not it? It lasted long after the acute effects of drug had worn off. “This could have important implications on the overall cardiac risk of these men." he said. Here is another shocking fact revealed. Viagra was initially a medicine for abnormal enlargement of heart. According to Dr. Susan Graham (cardiologist, UB-Kaleida), "Young men tried the medicine and several of them came back with this interesting side effect, and so it was developed and marketed for impotence." Researchers worldwide are experimenting continuously on Viagra and exploring unbelievable healing potentials in it. Viagra (sildenafil) not only prevents the heart from enlarging but also prevents stiffening of the muscle and improves heart function, which is already proven by various experiments throughout the nations. Viagra is playing Cupid, healing heart and assuring happy love-making as long as you live. We cannot deny it’s prospective in the medical field that can bring revolution in human lives. Just wait and watch! male penis elargement pnis enlargement device penis enargement before and after picture buy place vigrx penis enargement doctor penis enlagement picture penis enlargement pills review vigrx review penis enlarement pills

The prostate gland forms part of the male reproductive system and is responsible for the production of a clear liquid which makes up about thirty percent of the seminal fluid used to carry and protect the male sperm during intercourse. The prostate gland sits just below the bladder and in front of the rectum, partially surrounding the urethra which carries urine from the bladder out of the body. During childhood the prostate gland is very small (about the size of a pea) but will grow rapidly during puberty in response to the production of the male hormone testosterone. In a mature male the prostate is typically the size of a walnut and weighs about one ounce. The prostate gland is divided into the three sections – peripheral, central and transition. The peripheral section is located at the rear of the prostate gland and is the section of the prostate in which prostatitis and prostate cancer are most likely to develop. The transition section, which lies in the middle of the prostate gland and surrounds the urethra, is the area in which benign prostatic hyperplasia (BPH) is seen. There are a variety of problems associated with the prostate gland, the most common of which is BPH. This condition, which is a growth of non-cancerous cells within the transition section of the prostate gland causes an enlargement of the gland and exerts pressure on the urethra which, in turn, leads to difficulties in urinating. Other common problems include prostatitis, which is an inflammation or infection of the prostate gland, and prostate cancer. Enlargement of the prostate gland will affect about half of all men by the time they reach the age of 60 and increases with age to affect some ninety percent of the male population by the age of 80. Prostate cancer will affect approximately seventeen percent of the male population and results in the deaths of over 30,000 men each year in the United States alone. free penis enlargement tip free natural penis elargement top rated pnis enlargement pills pnis enlargement before and after picture penis enlargment pic penis enlargement device penis elargement pic free penis enlargment penis enlarement pills

If Spam were the ham-want-a-be instead of junk e-mail, I could say you are what you eat. That’s because Spam is supposed to be a reflection of who you are, based on the websites you visit and the cookies that follow you home. I have the obligatory bulk mail folder that fills up faster than the New Orleans levies during Katrina. But, it’s a social phenomenon that deserves closer scrutiny. In the interest of scientific investigation and self-diagnosis, I’ll share some recent e-mails and what it tells you about my pathetic life. I’ll break it down by e-mail subject and what I think it means. (1) Penis enlargements Cheap! – How do they know my size? (2) Refinance Before it’s Too Late – Too late for what? To pay the refinance charge? (3) Viagra on Sale – Is my poor performance showing? (4) Nigerian Attorney Needs Your Attention – I wonder what that’s all about? (5) Get Your Free I-Pod – Who says nothing is free anymore? (6) Get Paid While You Sleep _ Who said if you snooze, you lose. (7) Hot Chicks in Your Area – Does that mean the KFC around the corner? (8) E-Bay tips for Dummies – Who are you calling a dummy? (9) We have Found Your Missing Money – Did you go under my sofa cushions again? (10) Invitation From Donald Trump – I get to hear “You’re Fired” in person (11) Drug Rehab Center – Gotta kick that Tylenol (12) Stop Paying Taxes! – And start going to prison, right? (13) A Payday Loan to Cure Your Problem – Like getting stupid Spam mail? (14) Great Careers Opportunity – Did I mention I’m retired? (15) Party Poker Your Way – Like cheating to win? (16) Get Your Degree Online - I always wanted to be a rocket scientist. (17) A Woman Wants You – This must be from my daughter needing money (18) Costa Rica Land is Yours – Funny, I don’t remember ordering any. (19) Spanish Lottery Winner – Send me my pecos ASAP, por favor. (20) Gas Savings Instantly – Should I stop eating beans? So now you know all my inner-most secrets about where I go on the Internet in my spare time and how it judges me. I guess I should stick to the basic news and travel sites because they should be safe enough. Unless I decide that the “Baghdad Cruise Special” I just received, is worth checking out. pro solution pill review enlargement penis pill vimax vimax penis enlargement system does penis enlarement work penis enlarement before and after vimax natural penis enlargement pills penile enlargement technique penis enlargement information penis enlarement pills

Viagra (Sildenafil citrate), which millions of men take for erectile dysfunction (ED), reduces the effects of hormonal stress on the heart by half, according to a study published online in the journal Circulation. Viagra causes genital blood vessels to expand, which helps in maintaining an erection. Recent research also has pointed to its potential usefulness in treating pulmonary hypertension. Prior to the latest findings by a team of Johns Hopkins researchers, it was thought to have little effect on the heart. Viagra, or sildenafil, blunts the strengthened heart beat caused by chemically induced stress, according to study senior author and cardiologist David Kass, MD, a professor at the Johns Hopkins University School of Medicine and its Heart Institute. It thereby lessens both the excess amount of blood and the force used to pump it to the body. "Sildenafil effectively puts a 'brake' on chemical stimulation of the heart," says Kass. Prevents and Reverses Effects of High BP These findings are believed to be the first confirmation in humans that Viagra has a direct effect on the heart. In earlier research, Kass and his team observed a similar effect in mice; Sildenafil blocked the short-term effects of hormonal stress in the heart. Related studies by the group show that sildenafil also prevents and reverses the long-term effects of chronic high blood pressure on the heart. Sildenafil reversed the negative effects on heart muscle weakened by heart failure and enlargement -- a condition called hypertrophy -- in mouse experiments Kass and his team carried out earlier this year. They reported their results in the journal Nature Medicine. "But we had no firm evidence as to whether or how this therapy might work in the human heart," says Kass. "Our latest research provides firm evidence this drug does indeed have an important impact on the heart." Increased Heartbeat Was Slowed Thirty-five healthy men and women, with an average age of 30 and no previous signs of coronary artery disease, participated in the six-month Johns Hopkins study. Within a three-hour timeframe, each participant received two separate injections of dobutamine (5 micrograms per kilogram for five minutes), a synthetic, adrenaline-like chemical that increases heart rate and pumping strength. Between injections, study participants were assigned randomly to a group that was treated with sildenafil (100 milligrams taken orally) or to a group given a sugar pill placebo. All participants then were given the second dobutamine injection to see what effects sildenafil or placebo had on the heart. Measurements of heart function were made before and after each injection. These included blood pressure readings, electrocardiograms and echocardiograms. Blood samples confirmed relatively equal levels of sildenafil and other enzymes. Each dobutamine injection stimulated heart function, increasing heart rate and the force of each heartbeat used to pump blood throughout the body, results showed. "This stimulation is similar to the way the nervous system normally increases heart function when triggered by emotional or exercise stress, or in diseases such as heart failure," notes Kass. After the first injection of dobutamine, the force of heart contraction increased by 150 percent in both groups. In the placebo group, this increase repeated itself after the second injection. However, in the group treated with sildenafil, the increased heartbeat was slowed by 50 percent, resulting in a smaller increase in blood flow and blood pressure generated by the heart in response to chemical stimulation. Between injections, heart function was not altered in the sildenafil group, demonstrating the absence of adverse side effects on the resting human heart. Stops PDE5A Action "Knowing more about the effects of sildenafil on heart function will allow for safer evaluation of its use as a treatment for heart problems," says Kass. "Our results set the stage for further studies of sildenafil's immediate and long-term effects on the heart and its ability to modify other neurohormonal and stress stimuli, including adrenaline and hypertension," he adds. While the precise biological actions of sildenafil in the heart are not fully understood, the drug is known to work by stopping the action of an enzyme, called phosphodiesterase 5 (PDE5A), Kass explains. This enzyme is involved in the breakdown of a key molecule, cyclic GMP, which helps control stresses and limit overgrowth in the heart. PDE5A is also the biological pathway that sildenafil blocks in the penis to prevent the relaxation of blood vessels and thus maintain erections. Copyright 2005 Daily News Central