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Hey Viagra users! Do you know how your magic pill works on you? Hmmm…forgotten right! Or are you ignorant about its mechanism? Whatever, am sure about one thing you were startled after reading the title of this write-up! To understand Viagra mechanism we need to first understand how one gets a penis erection. Penile erection process is initiated with sexual excitement. The stimulation generates electrical impulses in the brain and sends it to the nerves going to the penile section. The nerve then releases nitric oxide to increase the production of cyclic GMP in muscle cells of corpus cavernosum simultaneously. Nitric oxide smoothes the muscles and increases the size of the blood vessels allowing high-speed blood flow to the penis. As a result the penis is engorged with blood making it firm and strong for penetrative sex. So what we understand from this is that the level of NO (Nitric oxide) is mainly responsible for giving a strong penile erection. Viagra does not have any direct relaxant effect on the penile section but it enhances the effect of nitric oxide by inhibiting phosphodiesterase type 5 (PDE5). When sexual stimulation leads to the release of Nitric oxide, the inhibition of PDE5 by Viagra causes increased levels of cyclic guanosine monophosphate which gives muscle relaxation and blood inflow to the corpus cavernosum which ultimately helps in getting the required erections of the penis. Now, I am sure you will be able to relate the Nobel Prize winner Dr. Furchgott with Viagra and its functioning. Nitric oxide was initially known as Endothelial Derived Relaxing Factor (EDRF), ERDF was released, when patients took the nitrate-type blood pressure medicines popular in the 1970s and 1980s, and in turn it caused relaxation of the smooth muscles around the blood vessels and the arteries became larger, allowing better blood flow and a lower blood pressure. In 1986, Dr. Furchgott identified the EDRF as nitric oxide. This is where the Viagra makers got the idea of a magic pill for sex which revolutionized the whole idea of impotence. They noticed from the research that the nitrate drugs had certain side-effects on the blood vessels and the arteries; relaxing the smooth muscles around the blood vessels thereby increasing the blood flows in the human body. They related it to the erectile anatomy and discovered Sildenafil citrate, a chemical that inhibited PDE5 inhibitors which is responsible for the level of NO (nitric oxide) in the penile section. Sildenafil Citrate, under the brand name of Viagra, became the pioneer pill for the treatment of erectile dysfunction and received FDA approval on March 27, 1998, the rest is history! After all a better blood flow is the key factor behind a strong erection. So the master mind behind Viagra, in a way, remains Dr. Furchgott, the inventor of nitric oxide. Without the knowledge of the existence of nitric oxide, no one could think of inhibiting phosphodiesterase type 5 to maintain the level of NO to get penis erection. Let’s toast for the good health of Dr. Furchgott and congratulate him on winning the Nobel Prize. Without his discoveries Viagra would not have been possible and millions of men with erectile dysfunction would have continued to live hopelessly and helplessly as ‘ashamed impotents’. Thanks Dr. Furchgott for everything you have given us through your discovery! penile enlargement secret manual penis enhancement enargement manhattan penis surgeon penis enlagement fact penile enlargement surgeon free penis elargement exercise vig rx penis pill discount vig rx
If you're expecting a baby boy you've probably noticed the circumcision debate. You may be wondering what you should do. Do you leave your son intact or have him circumcised? Circumcision is the removal of the foreskin from the glans of the penis. You should know that it is an amputation. Part of your son’s body will be forcibly torn from his penis and cut off. Advantages and Disadvantages Some parents choose circumcision for religious reasons. It is a religious practice for families practicing Judaism and Islam. Many Christian families also choose circumcision. There are other cultures throughout the world that circumcision is a traditional practice in. Though routine circumcision is traditional for some religions and cultures it is important to realize that thoughts on the surgery are changing. Many religious groups are giving up circumcision and choosing new rituals that do not hurt young boys. The Jewish ritual of Brit Shalom is one example. It is a time of peace and a celebration of the blessing of a son. Other parents choose to have their sons circumcised because they believe it is cleaner. It is true that an uncircumcised penis requires a little more work to keep clean, but it is only slightly more work. In the early years of a young boy's life cleaning is exactly the same. As a boy grows he can be taught to retract his own foreskin and rinse with warm water – just a young girl is taught to gently wash her genitals. A circumcised penis is actually more susceptible to infection in the early days, when it is a raw, open wound. Throughout the diapered years a little boy has slightly less protection from his own feces and the chemicals and fragrances that may be in his diapers. A Trend on the Decine The current trend in circumcision is a decline. No medical bodies anywhere in the world recommend routine circumcision. Some government insurance programs are dropping their coverage of the procedure. Fewer families are choosing to have their baby boys circumcised. By the time your son reaches school age the locker room may have more intact boys than it does circumcised boys. Some fathers want their sons to be the same as them. This is an issue you and your partner need to consider together. I encourage you to research it intensely, however. The choice you make about circumcising your son will have a lifelong impact on him. Take your religious and culture choices into account. Also be sure to read current medical literature. Know that organizations such as the American Academy of Pediatrics speak out against routine infant circumcision. Once you have thoroughly researched the procedure and all its possible complications you will know if it’s the right choice for your son. enlargement manhattan pennis surgeon truth about penile enlargement pills penis enlarement pills product permanent penis enhancement vimax penis enlargement forum free exercise tip for penile enlargement penis enlargement herb vimax penis enlargement without pills penis enlargment stretcher
Cialis is prescribed in cases of male erectile dysfunction. In other cases, many people have found that Cialis improves an already good sex life. They use Cialis as performance enhancer. That is fine as long as people are willing to acknowledge that they have a problem and they like the benefits that result. Cialis is not an aphrodisiac and it is not for everyone. To understand what is Cialis and how it works, I think that the following information are welcome. What is erectile dysfunction? Erectile dysfunction is the inability of the person to either initiate or sustain a penile erection for a sufficient period of time that is needed to attain a sexual gratification. The causes of it may be many for e.g. psychological, hormonal, arterial or muscular. What is erection? Erection is a process in which the penis becomes stiff and hard due to augmented blood flow. Erections may happen in response to physical or emotional stimulation, or sometimes an erection happens for no reason at all. Erection also enables sexual intercourse and some other sexual activities, though it is not essential for all of them. How the erection occurs? The penis contains two chambers called the corpora cavernosa, which run the length of the organ. When a man becomes aroused, the arteries leading into the penis open up so that pressurized blood can enter corpora cavernosa quickly. The blood creates pressure in the corpora cavernosa, making the penis expand and resulting the erection. What are the causes of erectile dysfunction? In most cases, physical causes of erectile dysfunction are very close related to blood flow circulation or nerve impulses to the penis. How Cialis works? As I said above, Cialis is not an aphrodisiac. It will not increase sexual drive. It only help people having disorders affecting the blood supply to the pelvis. Under sexual arousement Cialis' action relaxes muscles within the penis. This allows increased blood flow into the corpora cavernosa, very necessary to achieve and maintain a firm erection. Men with erectile dysfunction due to some arterial disorders will benefit the most. It doesn’t benefit those with hormonal problems or psychological problems except those with Diabetic neuropathy. vimax does penis enlargement work penis enlargment excercises penis enargement enlargment forum free matter penile size penis elargement surgery picture home pnis enlargement compare penile enlargment pills easy enlargment free penis surgery way penis enlargment stretcher
Question: Have plastic food and beverage containers been proven safe? Answer: No. During the film's graduation party in THE GRADUATE, Mr. McGuire pulls Benjamin Braddock (Dustin Hoffman) aside to offer sage advice for his future. His future would be one word: "plastics." Of course, we all know Mr. McGuire's advice and prognostication was correct. Plastics can only be made by man in his infinite wisdom, hence they are patentable. The profit in the manufacture of plastics has been huge. Plastics are everywhere. Plastic manufacturing now uses 4% of the world's oil production annually. Automobiles are now 9% plastic. It is of my special concern that more foods and beverages are being put into plastic containers. Plastics are ubiquitous now. They persist and accumulate in our society as their production exceeds their chemical degradation rate. Harmful chemicals from plastics are now commonly found in groundwater, waterways, and drinking water. While standing out in the summer heat in Phoenix, Arizona in 1981, my girlfriend asked me what was causing the film to form on the inside of the windshield of her new Mazda 626. She said that she had to wipe it off every morning so she could see to drive to work. I didn't know then. I do now! It was phthalates, the chemical that was added to the plastic dash cover to soften it and prevent cracking. I'm sure by now most of the phthalate has evaporated into our atmosphere and the Mazda is in some junkyard with a cracked up dash. Phthalates are EDC's (Endocrine Disrupting Chemicals.) They are chemicals found in recycle codes #1 through #6 plastics. Another EDC (Bisphenol A) is in recycle code #7 plastics. All of these types of plastic EDC's interfere with the function of sex hormones receptors. In THE GRADUATE Benjamin was quite a stud. I wonder if he's now taking one of the popular drugs to treat erectile dysfunction, a disorder that has become one of the many epidemics in our new plastic world. In 2003 a group of Croatian scientists reported that phthalates in plastics dissolved in various solutions. They used a variety of plastic items, including plastic food containers. After 10 days of sitting in distilled water, an average of 55.4 mg/ of phthalates from each kilogram of plastic "migrated" into the water. To a lesser degree the phthalates from plastics dissolved into acetic acid 3% (44.4 mg/kg) and 10% ethyl alcohol (32.3 mg/kg). The Croatian study shows what Benjamin would suspect, if he took chemistry in college: Water is the universal solvent; and it dissolves even the primarily fat soluble phthalates. The more that you filter water to remove other toxic solutes, the more aggressive water becomes in its power to reach osmolar equilibrium by dissolving its non-inert containers. What is also obviously missing from the Croatians' controlled, static testing model are the temperature variations that the plastic bottled water product goes through to get from bottling point to the mouth of the consumer. Transport trucks probably reach a very high temperature in the non refrigerated cargo areas that carry PETE (recycle code #1 plastic) bottled water in the summer. Heat facilitates the dissolution of phthalates into the water. Then the bottles may be stored for a much longer time than 10 days prior to consumption. Furthermore, freezing the containers produces micro-fissures in the interior surface of the plastic bottle container as the water expands, exponentially exposing more solute surface area. Traumatic handling or any motion of the package will further enhance diffusion. Applying the laws of physics, all of these factors clearly by extrapolation will increase the water dissolution of the plastic containers. Fatty foods in plastic containers are even more problematic, as fats are absorbed differently and carry their phthalate solvents into our bodies more easily. Phthalates bio-accumulate because of their fat solubility. Phthalates concentrate in such fat organs in our bodies such as brains, prostates, testicles, ovaries, breasts and, unfortunately, breast milk. (The other popular food alternatives for infants are worse. Commercial baby formulas are loaded with the manmade phthalates.) I think the worst example of food containment in plastic is milk. All milk except non-fat milk contains fat. Cow milk itself represents a major source of the fats ingested by the public, especially children. Cattle concentrate these chemicals by bioaccummulation because EDC's from plastics are ubiquitous in water and most animal food sources. Meat and dairy products are therefore a major contributor to this group of human food chain derived toxins, regardless of their containment. It is now irresponsible to add more phathalates to the products by putting the milk products in plastic containers that add MORE EDC's. Cattle have intentially been "fattened up" by adding hormones AND unintentially "fattened up" more by the contamination of cattle food and water by EDC's. The combination of these chemicals passed on to the consumers in concentrated form in milk products will most likely exacerbate obesity in humans that consume them as well. Our current scientific knowledge and common sense screams for an end to consumer purchase of milk bottled in plastics. Until milk companies have their products quantatatively analysed for these EDC's by competent independant laboratories, my strong recommendation is to avoid purchase and consumption of milk and dairy products contained in plastic. Sadly, the Croatian authors' 2003 conclusions about the safety of plastics were: "These (exposure) levels would not present a hazard for human health, not even for a prolonged period of time." However, what was deemed acceptable levels of phthalates in 2003 now is recognized as "crystal clearly" too high. Selective interpretations from the ACC (American Chemistry Council) lead to this erroneously high level being "set" for past toxicity standards. The ACC is an "industry group" advisor. It's much like the wolf guarding the henhouse. Thanks to the ACC efforts, control regulations placed upon this chemical class are minimal. An ongoing perpetuation of phthalate approval for use in virtually everything, including containment of food, has resulted. In fact, the perpetuation of these mythological high safety standards has resulted in the majority of our food being wrapped or contained in plastics that leach EDC's into our foods. The ACC's Phthalate Esters Panel is made up representatives from BASF, Eastman Chemical, Exxon-Mobil Chemical, Ferro, and Teknor Apex Corporations. After graduating, Benjamin could have gone to work for any of these companies to share the wealth that plastics manufacturing have reaped, instead of hanging around and sporting Mrs. Robinson for the summer! I love one of the rationalization examples the ACC makes on their PHTHALATES INFORMATION CENTER webpage: "Thanks to phthalates, your nail polish doesn't chip." I wonder if they are aware of the "unexplained" high rate of breast cancer in manicurists. I also wonder if they are aware that most breast tissues and breast cancers have sex hormone receptors that are acted upon by the EDC's found in plastics. To further confuse the public, the ACC webpage also redefines the PRECAUTIONARY PRINCIPLE which in its un-perverted definition simply is: A (chemical) should not be considered safe until it is proven safe. Environmentalists who are trying to unravel the cause-effect relationships of environment chemicals, to the otherwise unexplained epidemics of various diseases now affecting man as well as every species on our planet, encourage its application. The ACC's watered down version suggests that cost effective, fearless risks are worth taking. Can the ACC keep up the phthalate safety illusion forever? The American Tobacco Association almost got away with it! We now know that EDC's, like hormones themselves require very minute amounts to have physiologic impact. EDC's are active in parts per trillion! For example, the usual adult maintenance dose of levothyroxine, a drug to replace depleted natural thyroid hormone in hypothyroidism, is 1.6 micrograms/Kg/day. Why would I even think about saying that a dose in the milligrams (1000 times as much as a microgram) of a known EDC would be safe, especially for a child or developing fetus? We now know that phthalates also work in synergy with chemicals in other classes to exert "more than additive" physiologic effects. Previous experiments in rodents showed that high levels of phthalates interfer with testosterone during gestation resulting in birth defects of the genitalia, testicular cancer, and infertility in the rats. The ACC inspired acceptable level of phthalate myth should be blown out of the water with a recent study completed by the University of Rochester School of Medicine and Dentistry. This study of 85 human infant boys reported in May 2005 showed that phthalate levels found normally in the general population adversely influenced sexual development. The phthalate exposure these children had correlated with smaller penis size and incomplete testicular descent, which is a condition that greatly increases the risk of testicular cancer if left untreated. Solution 1 - Choose glass containers over plastic for purchase and storage of food and beverages including milk and water. American children can consume several milligrams of phthalate each day. I wonder if THE GRADUATE's Mr. Robinson noticed that most of the teenage girls now-days have bigger breasts than his seductive wife (gynecomastia), and that they begin thelarche (breast development) and menarche (menstruation) at a significantly younger age, or that many more have an endocrine pathology called PCOS (polycystic ovary syndrome). The chances of a woman getting breast cancer in her lifetime has probably gone from a risk of less than 1 in 10 (10%) before THE GRADUATE was made to a 1 in about 7.5 (13.2 %) rate today. The choice to avoid food chain plastics is a "no-brainer" when you understand how these chemicals persist and accumulate in our environment, and how they function in our bodies! Solution 2 - Choose stainless steel containers over plastic for storage of food and beverages including water. Unfortunately, we are past the point of no return with phthalates. Just like cigarettes I think we'll have to live as prisoners with their impact on future generations. The only defense we have at this time is to individually choose to avoid them when we can, to mitigate their effects on our health. Phthalates clearly act upon hormone receptors in both men and women. A concern is the potential phthalate impact on breast and other hormone sensitive tissue in human females, but phthalate's demasculinizing potential on males is more of a threat to all species on the planet. Unlike Mr. McGuire, I think we can choose a better future by avoiding his "one word." We should start by trying to reduce plastics in our food chain exposures. Bottom line: I would strongly advise consumers to purchase beverages and non-solid food products packaged in glass rather than plastic if given the choice. © Life Dynamix 2005 All Rights Reserved best penis enlargment surgery penis enhancement pills product vigrx ingredient com enlargement pnis pnis pump semenax vigrx penis enlarement exercise pnis enlargement cheapest penis enargement pills penis enlargment stretcher
The greatest source of discomfort for cyclists is the nose of their bike seat pressing on nerves and soft tissues. For men, this pain brings the additional worry of impotence. Impotence is caused by nerve and artery damage. Exercising regularly helps to keep arteries healthy, so bicycling helps prevent impotence, as long as it does not damage the local arteries and nerves. Recent studies show that three percent of regular male bicycle riders become impotent, and virtually all of them felt pain or numbness before the problem occurred. When a nerve is pinched or the blood supply is shut off to the penis, a man feels numb. Men who ride with conventional bicycle seats and do not feel numb are not likely to be at risk. If you feel no discomfort when you ride, keep on riding and stop worrying. If you feel numbness, get a new seat. Half of the penis is inside the body and the main blood supply comes from the area just behind the scrotum and in front of the rectum. So bicycle seats that press on that area can cause impotence, while those that do not have a nose and have a widened area to hold your weight on your sitz bones should prevent the problem. Some entrepreneurs developed seats that have holes in the middle. Their theory is that if there is no pressure behind the scrotum, there will be no numbness. However, no good studies show that these seats prevent numbness and therefore prevent impotence, because the nose in front of the hole still exerts pressure on the nerves and arteries. They may make the problem worse because the pressure on an area increases as an area deceases. Making a hole in the middle decreases the surface area of the saddle and therefore increases the pressure on the arteries and nerves. The best way to avoid pressure on the arteries that carry blood to the penis is to use a saddle without any nose. I use a rectangular-shaped seat with rounded edges in the front, called The Seat by Ergo. Similar designs are available from The Solution Bicycle Seat, Easyseat, Spongywonder and Spiderflex brands. The Seat is wide enough to allow me to put my weight on the sitz bones of my pelvis instead of my crotch. I never suffer numbness and don't worry about impotence, but it doesn't work for everyone. Racers need to have a bicycle seat nose between their legs to help control the bicycle with their legs, but if you have no need to ride with both hands off the handle bars at the same time, you should be able to use a nose-less seat. Nose-less seats force you to bend forward. To keep yourself from falling, you have to hold yourself up on your handlebars. This puts a lot of pressure on your shoulders arms and hands, so you must strengthen your upper body and change positions often. Other tips for comfort in a bicycle seat include: 1) Avoid seats with excessive padding. The greater the padding, the deeper you sink into the saddle and the more likely you are to feel numbness. 2) Use gel saddles. They are not too hard and not too soft. 3) Never tilt the saddle nose upward. The seat should be level or angle downward slightly. 4) Set your handlebars higher so that you do not have to bend forward. The lower you bend, the greater the pressure on your perineum. 5) Ride a more upright position. However, this increases wind resistance and will slow you down. 6) Change positions often as you ride. 7) Wear thin padding in your pants. Most good bicycle pants come with form-fitted chamois padding.